Selected Publications

Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.

Fletcher EV, Simon CM, Pagiazitis JG, Chalif JI, Vukojicic A, Drobac E, Wang X, Mentis GZ.

Nature Neuroscience (2017) 20: 905-916.    Pubmed
A stem cell model of the motor circuit uncouples motor neuron death from hyperexcitability induced by SMN deficiency.

Simon CM*, Janas AM*, Lotti F, Tapia JC, Pellizzoni L**, Mentis GZ**.
* equal contribution, ** co-corresponding authors

Cell Rep. (2016) 16:1416-1430.    Pubmed

Sensory-derived glutamate regulates presynaptic inhibitory terminals in mouse spinal cord.

Mende M*, Fletcher EV*, Belluardo JL*, Pierce JP, Bommareddy PK, Weinrich JA, Kabir ZD, Schierberl KC, Pagiazitis JG, Mendelsohn AI, Francesconi A, Edwards RH, Milner TA, Rajadhyaksha AM, van Roessel PJ, Mentis GZ**, Kaltschmidt JA**.
* equal contribution, ** co-corresponding authors
Neuron (2016) 15: 1189-1202.    Pubmed 

Spinal inhibitory interneuron diversity delineates variant motor microcircuits.

T Bikoff JB, Gabitto MI, Rivard AF, Drobac E, Machado TA, Miri A, Brenner-Morton S, Famojure E, Diaz C, Alvarez FJ, Mentis GZ, Jessell TM.

Cell (2016) 165: 207-219.     Pubmed

ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function.

Sharma A, Lyashchenko AK, Lu L, Nasrabady Ebrahimi S, Elmaleh M, Mendelsohn M, Nemes A, Tapia JC, Mentis GZ, Shneider NA.

Nature Communications (2016) 7:10465     Pubmed

Activity regulates the incidence of heteronymous sensory-motor connections.

Mendelsohn AI, Simon CM, Abbott LF, Mentis GZ, Jessell TM.

Neuron (2015) 87:111-123.    Pubmed
SMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3'-end formation of histone mRNAs.

Tisdale S, Lotti F, Saieva L, Van Meerbeke JP, Crawford TO, Sumner CJ, Mentis GZ, Pellizzoni L.

Cell Rep. (2013) 5:1187-1195.    Pubmed
An SMN-dependent U12 splicing event essential for motor circuit function.

Lotti F, Imlach WL, Saieva L, Beck ES, Hao le T, Li DK, Jiao W, Mentis GZ, Beattie CE, McCabe BD, Pellizzoni L.

Cell (2012) 151:440-454.  Pubmed
Early functional impairment of sensory-motor connectivity in a mouse model of spinal muscular atrophy.

Mentis GZ, Blivis D, Liu W, Drobac E, Crowder ME, Kong L, Alvarez FJ, Sumner CJ, O'Donovan MJ.

Neuron (2011) 69:453-467.    Pubmed
Mechanisms regulating the specificity and strength of muscle afferent inputs in the spinal cord.

Mentis GZ, Alvarez FJ, Shneider NA, Siembab VC, O'Donovan MJ.

Ann N Y Acad Sci. (2010) 1198:220-230.     Pubmed