Complete List of Published Work by George Z. Mentis (in MyBibliography):

NCBI
Selected Publications
SplC3D imaging for spinal in situ contrast 3D visualization.


Liang L, Fasse A, Damiani A, Jantz MK, Agbor U, Del Brocco M, Monney R, Rowland C, Newton T, Gopinath C, Schaeffer DJ, Kolarcik CL, Pagiazitis JG, Mentis GZ, Fisher LE, Neufeld E, Capogrosso M, Gaunt RA, Hitchens TK, Pirondini E.

Cell Report Methods. (2025) 5(10):101202. Pubmed 
Synaptic imbalance and increased inhibition impair motor function in SMA.


Fletcher EV,  Chalif JI, Rotterman TM, Pagiazitis JG, Van Alstyne M, Sivakumar N, Florez-Paz D, Rabinowitz JE, Pellizzoni L, Alvarez FJ, Mentis GZ. 


Science Advances (2025) 11(36):eadt4126. Pubmed
Proprioceptive synaptic dysfunction is a key feature in mice and humans with spinal muscular atrophy.

Simon CM, Delestrée N, Montes J, Sowoidnich L, Gerstner F, Carranza E, Buettner JM, Pagiazitis JG, Prat-Ortega G, Ensel S, Donadio S, Dreilich V, Carlini MJ, Garcia JL, Kratimenos P, Chung WK, Sumner CJ, Weimer LH, Pirondini E, Capogrosso M, Pellizzoni L, De Vivo DC, Mentis GZ.

Brain (2025) 148:2797-2811. The COVER is from our study. Pubmed
First-in-human study of epidural spinal cord stimulation in individuals with spinal muscular atrophy.

Prat-Ortega G, Ensel S, Donadio S, Borda L, Boos A, Yadav P, Verma N, Ho J, Carranza E, Frazier-Kim S, Fields DP, Fisher LE, Weber DJ, Balzer J, Duong T, Weinstein SD, Eliasson MJL, Montes J, Chen KS, Clemens PR, Gerszten P, Mentis GZ, Pirondini E, Friedlander RM, Capogrosso M.

Nat Med. (2025) 31:1246-1256. Pubmed
Catecholaminergic dysfunction drives postural and locomotor deficits in a mouse model of spinal muscular atrophy.

Pagiazitis JG, Delestrée N, Sowoidnich L, Sivakumar N, Simon CM, Chatzisotiriou A, Albani M, Mentis GZ.

Cell Rep. (2025) 44:115147. Pubmed
Serotonergic dysfunction impairs locomotor coordination in spinal muscular atrophy.

Delestrée N, Semizoglou E, Pagiazitis JG, Vukojicic A, Drobac E, Paushkin V, Mentis GZ.

Brain. (2023) 146:4574-4593. Pubmed
Control of mammalian locomotion by ventral spinocerebellar tract neurons.

Chalif JI, Martínez-Silva ML, Pagiazitis JG, Murray AJ, Mentis GZ.

Cell. (2022) 185:328-344. Pubmed
SMN controls neuromuscular junction integrity through U7 snRNP.

Tisdale S, Van Alstyne M, Simon CM, Mentis GZ, Pellizzoni L.

Cell Rep. (2022) 40:111393. Pubmed
Sumoylation regulates the assembly and activity of the SMN complex.

Riboldi GM, Faravelli I, Kuwajima T, Delestrée N, Dermentzaki G, De Planell-Saguer M, Rinchetti P, Hao LT, Beattie CC, Corti S, Przedborski S, Mentis GZ, Lotti F.

Nat Commun. (2021) 12:5040. Pubmed
Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit.

Van Alstyne M, Tattoli I, Delestrée N, Recinos Y, Workman E, Shihabuddin LS, Zhang C, Mentis GZ, Pellizzoni L.

Nat Neurosci. (2021) 24:930-940. Pubmed
Molecular correlates of muscle spindle and Golgi tendon organ afferents.

Oliver KM, Florez-Paz DM, Badea TC, Mentis GZ, Menon V, de Nooij JC.

Nat Commun. (2021) 12:1451.  Pubmed
Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA.

Kong L, Valdivia DO, Simon CM, Hassinan CW, Delestrée N, Ramos DM, Park JH, Pilato CM, Xu X, Crowder M, Grzyb CC, King ZA, Petrillo M, Swoboda KJ, Davis C, Lutz CM, Stephan AH, Zhao X, Weetall M, Naryshkin NA, Crawford TO, Mentis GZ, Sumner CJ.

Sci Transl Med. (2021) 13(578):eabb6871 Pubmed
Chronic Pharmacological Increase of Neuronal Activity Improves Sensory-Motor Dysfunction in Spinal Muscular Atrophy Mice.

Simon CM, Blanco-Redondo B, Buettner JM, Pagiazitis JG, Fletcher EV, Sime Longang JK, Mentis GZ.

J Neurosci. (2021) 41:376-389. Pubmed
Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy.

Simon CM, Van Alstyne M, Lotti F, Bianchetti E, Tisdale S, Watterson DM, Mentis GZ, Pellizzoni L.

Cell Reports (2019) 29:3885-3901.    Pubmed
The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA.

Vukojicic A, Delestrée N, Fletcher EV, Pagiazitis JG, Sankaranarayanan S, Yednock TA, Barres BA, Mentis GZ.

Cell Reports (2019) 29:3087-3100.    Pubmed
Subtype Diversification and Synaptic Specificity of Stem Cell-Derived Spinal Interneurons.

Hoang PT, Chalif JI, Bikoff JB, Jessell TM, Mentis GZ, Wichterle H.

Neuron (2018) 100:135-149.    Pubmed
Dysregulation of Mdm2 and Mdm4 alternative splicing underlies motor neuron death in spinal muscular atrophy.

Van Alstyne M, Simon CM, Sardi SP, Shihabuddin LS, Mentis GZ, Pellizzoni L.

Genes & Development (2018) 32:1045-1059.   Pubmed
Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody.

Cantor S, Zhang W, Delestrée N, Remédio L, Mentis GZ, Burden SJ.

Elife (2018) 7. pii: e34375.  Pubmed
Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy.

Simon CM, Dai Y, Van Alstyne M, Koutsioumpa C, Pagiazitis JG, Chalif JI, Wang X, Rabinowitz JE, Henderson CE, Pellizzoni L, Mentis GZ.

Cell Reports (2017) 21:3767-3780.   Pubmed

Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy.

Fletcher EV, Simon CM, Pagiazitis JG, Chalif JI, Vukojicic A, Drobac E, Wang X, Mentis GZ.

Nature Neuroscience (2017) 20: 905-916.    Pubmed
A stem cell model of the motor circuit uncouples motor neuron death from hyperexcitability induced by SMN deficiency.

Simon CM*, Janas AM*, Lotti F, Tapia JC, Pellizzoni L**, Mentis GZ**.
* equal contribution, ** co-corresponding authors

Cell Rep. (2016) 16:1416-1430.    Pubmed

Sensory-derived glutamate regulates presynaptic inhibitory terminals in mouse spinal cord.

Mende M*, Fletcher EV*, Belluardo JL*, Pierce JP, Bommareddy PK, Weinrich JA, Kabir ZD, Schierberl KC, Pagiazitis JG, Mendelsohn AI, Francesconi A, Edwards RH, Milner TA, Rajadhyaksha AM, van Roessel PJ, Mentis GZ**, Kaltschmidt JA**.
* equal contribution, ** co-corresponding authors
Neuron (2016) 15: 1189-1202.    Pubmed 

Spinal inhibitory interneuron diversity delineates variant motor microcircuits.

T Bikoff JB, Gabitto MI, Rivard AF, Drobac E, Machado TA, Miri A, Brenner-Morton S, Famojure E, Diaz C, Alvarez FJ, Mentis GZ, Jessell TM.

Cell (2016) 165: 207-219.     Pubmed
Diverging roles for Lrp4 and Wnt signaling in neuromuscular synapse development during evolution.

Remédio L, Gribble KD, Lee JK, Kim N, Hallock PT, Delestrée N, Mentis GZ, Froemke RC, Granato M, Burden SJ.

Genes & Development (2016) 30:1058-69.   Pubmed

ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function.

Sharma A, Lyashchenko AK, Lu L, Nasrabady Ebrahimi S, Elmaleh M, Mendelsohn M, Nemes A, Tapia JC, Mentis GZ, Shneider NA.

Nature Communications (2016) 7:10465     Pubmed

Activity regulates the incidence of heteronymous sensory-motor connections.

Mendelsohn AI, Simon CM, Abbott LF, Mentis GZ, Jessell TM.

Neuron (2015) 87:111-123.    Pubmed
SMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3'-end formation of histone mRNAs.

Tisdale S, Lotti F, Saieva L, Van Meerbeke JP, Crawford TO, Sumner CJ, Mentis GZ, Pellizzoni L.

Cell Rep. (2013) 5:1187-1195.    Pubmed
An SMN-dependent U12 splicing event essential for motor circuit function.

Lotti F, Imlach WL, Saieva L, Beck ES, Hao le T, Li DK, Jiao W, Mentis GZ, Beattie CE, McCabe BD, Pellizzoni L.

Cell (2012) 151:440-454.  Pubmed
Early functional impairment of sensory-motor connectivity in a mouse model of spinal muscular atrophy.

Mentis GZ, Blivis D, Liu W, Drobac E, Crowder ME, Kong L, Alvarez FJ, Sumner CJ, O'Donovan MJ.

Neuron (2011) 69:453-467.    Pubmed
Mechanisms regulating the specificity and strength of muscle afferent inputs in the spinal cord.

Mentis GZ, Alvarez FJ, Shneider NA, Siembab VC, O'Donovan MJ.

Ann N Y Acad Sci. (2010) 1198:220-230.     Pubmed